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Multi-Color TIRF System Provides Fast Wavelength Switching

The AM TIRF MC (multi-color, total internal reflection fluorescence) system now allows the entire fluorescence excitation spectrum to be used for real-time visualization of live cell dynamics. The scanner sensor automatically matches the TIRF angle at all wavelengths to the required penetration depth and positions the laser so the TIRF penetration depth remains constant even when the wavelength is changed. The system integrates four solid-state lasers for the excitation of fluorophores at wavelengths from 405 to 632 nm. Additional features include extremely short switching times and an ultra-high synchronized frame rate. This provides superior flexibility for experiments with multiple fluorophores. The system is also useful for exploring molecular interaction at cell membranes and molecular interaction of proteins and receptors involved in transport mechanisms. With the system, users can examine single molecules near the cell membrane, study co-localization and vesicle transport, and combine TIRF and fast FRET analysis.

Leica Microsystems Inc.
2345 Waukegan Rd.
Bannockburn, IL, 60015