News: - Scientists Crack Genetic Secrets of Human Egg - Dartmouth and GlycoFi Report Full Humanization of Therapeutic Proteins from Yeast - Boston College Chemists’ Catalyst Discovery Promises Faster, Less Expensive Drug Production - Researchers Map Out Networks That Determine Cell Fate

Editor's Choice: - Centrifugal Evaporators Include Methods for Drying Aqueous Samples - Compact Chiro-Optical Spectrometer - High-Sensitivity Microarray Slides - LIBS System Provides Real-Time Spectral Analysis of Elements - Automated, Robotic Liquid Handling Workstations - Desktop-Portable Image Analysis System

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Dartmouth and GlycoFi Report Full Humanization of Therapeutic Proteins from Yeast
Researchers at Dartmouth's Thayer School of Engineering, Dartmouth Medical School, and the biotechnology firm GlycoFi, Inc., report a significant advance in the production of therapeutic proteins. Reported in the Sept. 8 issue of the journal Science, the Dartmouth/GlycoFi team announced the complete humanization of the glycosylation pathway in the yeast Pichia Pastoris.

"We've successfully completed one of the most complex cellular engineering endeavors undertaken to date," said Tillman Gerngross, chief scientific officer of GlycoFi and professor of engineering at Dartmouth. more>>>

Boston College Chemists’ Catalyst Discovery Promises Faster, Less Expensive Drug Production
Boston College chemists have discovered a substance that will make it possible for scientists to produce scores of pharmaceuticals and other chemicals in a faster, less expensive way.

“Our new catalyst will significantly improve the efficiency with which biologically and medicinally active molecules can be prepared,” said Prof. Hoveyda, who is also chair of the department. “Such a catalyst, by shortening synthesis routes, will significantly lower cost and reduce the waste generated in laboratory syntheses.” more>>>




Researchers Map Out Networks That Determine Cell Fate
A two-step process appears to regulate cell fate decisions for many types of developing cells, according to researchers from the University of Chicago.

This finding sheds light on a puzzling behavior. For some differentiating stem cells, the first step leads not to a final decision but to a new choice. In response to the initial chemical signal, these cells take on the genetic signatures of two different cell types. It often requires a second signal for them to commit to a single cellular identity.

In the Aug. 25 2006 issue of Cell, the researchers, working with hematopoietic stem cells, which give rise to the many types of blood cells, show how "pioneer transcription factors" trigger the first step, pushing these stem cells towards this mixed lineage, midway between two related cell types — in this case between a macrophage and a neutrophil. more>>>

Centrifugal Evaporators Include Methods for Drying Aqueous Samples Genevac’s miVac centrifugal evaporator is suited for labs that use large numbers of membranes per year. The sample concentration technique ensures complete sample recovery, even when taking proteins to very high concentrations. In most biological applications, the units deliver careful and speedy drying. more>>>

Compact Chiro-Optical Spectrometer JASCO’s J-815 chiro-optical spectrometer features a compact design and a wavelength range of 163 to 900 nm. With an optional 21 CFR Part 11 compliant package, Spectra Manager II software control is standard for instrument control and data analysis. more>>>

High-Sensitivity Microarray Slides Genewave’s AmpliSlide range of high-sensitivity reflective microarray slides combines a proprietary, fluorescence-amplifying dielectric coating with highly efficient binding chemistries. AmpliSlide 570/670 A (aminosilane) is suited for double color DNA microarray experiments. The reflective coating provides signal enhancement balanced in both colors. more>>>

LIBS System Provides Real-Time Spectral Analysis of Elements New Wave Research’s fully integrated LIBS-Elite laser-induced-breakdown spectrometer provides real-time, high-resolution spectral analysis of elements in a variety of materials down to 1 ppm. No sample preparation is required. The user simply places a sample in the chamber, programs the system for about 30 seconds and receives spectra within moments. more>>>

Automated, Robotic Liquid Handling Workstations Caliper Life Sciences’ Sciclone family of liquid handling workstations offers fast, reliable and scalable automation solutions for drug discovery applications. The Sciclone i1000 features multi-MEMS technology to provide accurate, independent control of 96 single-channel pipetting heads for high volume applications. more>>>
	Desktop-Portable Image Analysis System Fujifilm Life Science’s LAS-3000mini CCD analyzes chemiluminescence and bioluminescence, specifically in Western blotting applications. The Super CCD chip enables a resolution of 3.2- to 6.3-million pixels. The F0.85 FUJINON high-sensitivity lens captures faint images such as expression of calcium-binding proteins. more>>>